February 19, 2017

A cautionary word about fat stem cell treatments

CAUTION SIGN - FREE MS GRAPHICThe use of fat stem cells is not without risk, something brought into sharp focus late last year (2012) when stories surfaced in the media concerning a lady in Los Angeles who had a cosmetic procedure in which mesenchymal stem cells isolated from her own harvested fat were injected around her eyes along with a FDA approved dermal filler used to reduce wrinkles. The dermal filler contained calcium hydroxylapatite which nudged the stem cells to become bone which had to then be surgically removed. If you didn’t catch this story you can read about it by clicking this link.

Fat tissue is rich in biologically versatile mesenchymal stem cells and for this reason many researchers and doctors justifiably feel they could revolutionize some aspects of medicine. Not surprisingly doctors in the US and abroad, especially cosmetic surgeons, latched on to fat stem cells and began employing them in various guises (purified, minimally manipulated, etc.) to do cosmetic procedures and treat various diseases and medical conditions. Physician and adult (nonembryonic) stem cell expert Dr. David Steenblock worked for a very brief time with adipose stem cells but abandoned them for a number of reasons including certain safety concerns (More on this below), the FDA’s classification of them as constituting a new drug (Click to read more), and the fact they did not produce healing outcomes greater than what he had seen in the stem cell-rich bone marrow aspirate treatments he has been doing had doing since 2005 (Nota bene: Dr. Steenblock processes the stem cell-rich bone marrow aspirate he employs to treat patients in a way that fully complies with the FDA’s rules concerning minimum manipulation. Click to read his clinic’s statement of compliance).

One clinically defining difference between fat stem cells and those from bone marrow is this: While bone marrow stem cells naturally migrate from bone into all our bloodstreams and then make their way to tissues and organs through the human body including the brain where they participate in repair and restorative activities, something which constitutes a natural healing mechanism and health supportive role for bone marrow stem cells, the same cannot be said of fat stem cells. They are not, for instance, summoned to the brain when injury or disease strikes.

Of course, many foreign clinics use a patient’s own fat stem cells to treat a variety of diseases and there are certainly many glowing patient stories and very few horror stories connected with these treatments. With this said, this hardly constitutes credible proof that there are no risks connected with this, especially long term. We are, after all, not talking about augmenting a natural mechanism – adding bone marrow stem cells to shore up already mobilized and engrafted bone marrow – but introducing fat stem cells which are not normally part of nature’s own healing kit.

For adults with serious diseases who have little to lose long term by doing a treatment or series of treatments involving fat derived stem cells, Dr. Steenblock does caution them to make sure they have no tumors or microtumors in their body. Why? There is evidence that fat tissue progenitor cells naturally gravitate to tumors and participate in processes linked to their growth and perhaps spread (Two abstracts concerning this follow below). To infuse a patient who has such tumors or microtumors with fat stem cells would thus be akin to throwing gasoline on a fire.  

Naturally Dr. Steenblock is concerned that foreign clinics and renegade ones in the US that process fat stem cells beyond what the FDA allows may be putting their patients (especially young folks) at elevated risk of complications and other problems down the road

Anyone needing reliable, sound advice concerning stem cell therapies is invited to call Dr. Steenblock’s Clinic at 1-800-300-1063 (9 am to 5 pm Pacific Time, Monday through Friday) to arrange for a FREE consultation.

 

References

http://www.cosmeticsurg.net/blog/2012/01/11/fda-stem-cells-from-your-own-fat-are-a-drug/FDA: Stem Cells from Your Own Fat are a Drug

http://www.nature.com/stemcells/2007/0712/071220/full/stemcells.2007.131.html – “Circulating stem cells – Haematopoietic stem cells patrol the body to ward off infection” in Nature Reports Stem Cells
Published online: 20 December 2007 | doi:10.1038/stemcells.2007.131

 http://www.ncbi.nlm.nih.gov/pubmed/23038706Human periprostatic white adipose tissue is rich in stromal progenitor cells and a potential source of prostate tumor stroma

Abstract

A body of growing evidence now implicates white adipose tissue as a relevant source of stromal progenitor cells recruited to the tumor microenvironment to form supportive tumor stroma. While the role of periprostatic (PP) adipose tissue in prostate cancer progression has been barely appreciated, we sought to determine the progenitor cell population in PP adipose tissue and the association with prostate cancer. We isolated and characterized CD31(-)CD34(+)CD45(-)CD146(-) progenitor cells (adipose-derived stem cells [ASC]) in paired samples of PP and preperitoneal visceral adipose tissue from prostate tissue and peripheral blood mononuclear cells of prostate cancer and nodular prostatic hyperplasia patients. ASC were quantified by flow cytometry and confirmed through target gene expression. Here we show a significantly higher amount of ASC in PP than in visceral adipose tissue, independent of body mass index and prostatic disease. In the prostate, ASC are increased in cancer compared with prostatic nodular hyperplasia patients. Concordantly, adipsin gene (CFD) expression, which is known to be up-regulated in adipose stem cells, was overexpressed in PP adipose tissue, in the prostate of cancer patients and in prostate CD31(-)CD34(+)CD45(-)CD146(-) sorted cells. ASC were found at higher levels in the blood of prostate cancer patients simultaneously overweight/obese. Present findings indicate that PP adipose tissue is a reservoir of progenitor cells with the potential to migrate towards prostate tumors, although its clinical significance merits further evaluation.

PMID: 23038706

 

http://www.ncbi.nlm.nih.gov/pubmed/21607127Adipose tissue-derived progenitor cells and cancer

Abstract

Recruitment of stem cells and partially differentiated progenitor cells is a process which accompanies and facilitates the progression of cancer. One of the factors complicating the clinical course of cancer is obesity, a progressively widespread medical condition resulting from overgrowth of white adipose tissue (WAT), commonly known as white fat. The mechanisms by which obesity influences cancer risk and progression are not completely understood. Cells of WAT secret soluble molecules (adipokines) that could stimulate tumor growth, although there is no consensus on which cell populations and which adipokines are important. Recent reports suggest that WAT-derived mesenchymal stem (stromal) cells, termed adipose stem cells (ASC), may represent a cell population linking obesity and cancer. Studies in animal models demonstrate that adipokines secreted by ASC can promote tumor growth by assisting in formation of new blood vessels, a process necessary for expansion of tumor mass. Importantly, migration of ASC from WAT to tumors has been demonstrated, indicating that the tumor microenvironment in cancer may be modulated by ASC-derived trophic factors in a paracrine rather than in an endocrine manner. Here, we review possible positive and adverse implications of progenitor cell recruitment into the diseased sites with a particular emphasis on the role in cancer progression of progenitors that are expanded in obesity.

FULL PAPER: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097931/

Dr. Steenblock’s Clinic in compliance with state & federal regulations & guidelines

1. Dr. Steenblock’s Clinic has been doing bone marrow aspirate treatments since 2005 for various chronic medical conditions. The bone marrow harvested from patients is never processed beyond the FDA’s minimum manipulation guidelines & regulations (http://www.gpo.gov/fdsys/pkg/FR-1998-05-14/html/98-12751.htm  Page 26,748). Thus Dr. Steenblock’s bone marrow treatment is FDA compliant and falls under the practice of medicine (And use of bone marrow aspirate to treat patients is not forbidden under California statutes governing the practice of medicine)

The use of bone marrow aspirate is part of an in-office medical exploration tradition that has been part of American medicine for centuries. It is the kind of work that has historically led to many new discoveries and the generation of many viable hypotheses.

No short or long term adverse effects or harm has cropped up among Dr. Steenblock’s bone marrow aspirate patients (Approximately 1500 to-date). And while the case history or anecdotal data and information Dr. Steenblock has gleamed from his on-going work with bone marrow aspirate treatments do not constitute “hard evidence” of efficacy, this sort of proof has a place in medicine and historically has driven many innovations and new developments.

Anecdotal Evidence: Why Narratives Matter to Medical Practice” by Rafael Campo

http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0030423

2.  Dr. Steenblock does not harvest, process or use stem cell rich adipose tissue for any purpose whatsoever. He was trained to process and use adipose derived tissue cells to treat patients and did so for a short time but ceased doing so after the FDA declared that fat cells so processed constitute a “new drug”.

3. Patients whom Dr. Steenblock feels might benefit from treatment with pure umbilical cord stem cells are referred to clinics in Mexico that offer this kind of treatment.

4. Dr. Steenblock’s nonprofit Steenblock Research Institute tracks patients treated with umbilical cord stem cells in Mexico to determine outcomes and also provides education and information on adult (nonembryonic) stem cells and stem cell treatments done abroad to people seeking this sort of thing. SRI also has a massive medical library and a fully equipped molecular biology lab where bench research is being done using adult (nonembryonic) stem cells.

The other side of the story

Dr. SteenblockOccasionally a browser will ask about negative articles concerning Dr. Steenblock that appear on the Internet. If you have come across these and wondered if there was a flip side to these, there is and you can now read “the other side of the story” (as the late radio broadcaster Paul Harvey was fond of saying.)  These links will whisk you to material that will fill in the blanks and help set the record straight:

Special issue of Dr. Steenblock’s Newsletter that takes on the “dark press” about him and his work

Goliath v. David

Ecce signum!

Ready to move beyond “prescription pad” medicine?

Dr. SteenblockDuring the past forty years medical trailblazer Dr. David Steenblock has refused to accept the status quo or dispense “medicine platitudes.” Rather than tell a suffering patient to accept or “embrace” their pain and discomfort, he makes war on disease by finding or making solutions. Not surprisingly he often pushes the envelope to do this. If you are ready to move beyond status quo medicine, check out what Dr. Steenblock and his staff of medical innovators have to offer. No strings or obligation. To arrange for your consultation just call 1-800-300-1063.  

Have you been misdiagnosed? Misdiagnoses are fairly common.

Dr. SteenblockHave you been Misdiagnosed? Come see Dr. Steenblock

Have you ever wondered how often doctors misdiagnose? One on-line report that delves in to this is titled “How Common is Misdiagnosis?” and appears on WrongDiagnosis.Com. Here is one salient portion from that insightful piece:

The National Patient Safety Foundation (NPSF) commissioned a phone survey in 1997 to review patient opinions about medical mistakes. Of the people reporting a medical mistake (42%), 40% reported a “misdiagnosis or treatment error”, but did not separate misdiagnosis from treatment errors. Respondents also reported that their doctor failed to make an adequate diagnosis in 9% of cases, and 8% of people cited misdiagnosis as a primary causal factor in the medical mistake. Loosely interpreting these facts gives a range of 8% to 42% rate for misdiagnoses.

http://www.wrongdiagnosis.com/intro/common.htm

I’m not here to knock doctors for being fallible. It is, after all, a “universal affliction” among our species. Of course, the consequences of physician misdiagnoses exact a toll in the sense of wrong treatments implemented and right treatments delayed or never done. Some on the receiving end of wrong diagnoses no doubt suffer terribly due to being misdiagnosed and I’m sure some wind up prematurely deceased.  And while new and better diagnostic tests, equipment and software promise to help drive the rate of misdiagnosis steadily downward, it is doubtful that this will totally eliminate it. After all, making a diagnosis requires not just test results, but their interpretation by a skilled physician who draws on his education, experience and professional judgment.

To my way of thinking, one sure way for a doctor to set a course to becoming a first rate diagnostician is to spend the early part of his career in pathology, which is a medical specialty devoted to the study and diagnosis of disease. USC’s Keck School of Medicine Department of Pathology website puts it this way: ‘Pathology is a medical specialty that provides the scientific foundation for all medical practice. The pathologist works with each of the clinical specialties, using the tools of laboratory medicine to provide information essential to problem solving in clinical practice. As such, the pathologist is the “doctors’ doctor.”’

One physician who actually became a pathologist before venturing into medical practice was none other than this blog sites’ namesake and focus, Dr. David A. Steenblock.

Not surprisingly, Dr. Steenblock has an impressive track record of not just making correct medical diagnoses, but also in readily spotting misdiagnoses. As a result he has saved many patients from wasting their time and resources treating the wrong problem.  I have, in fact, talked with more than a few folks who had Dr. Steenblock go through their medical records and zero in on telltale test or scan results that overturned the diagnosis they had been given, which set the stage for their being properly diagnosed and then successfully treated.

If you have been handed a diagnosis you question, take your case to a first rate diagnostician for a proverbial second opinion.  If you’d like to retain Dr. Steenblock for this purpose, he is more than willing and able to lend a helping hand.  To learn more visit his website or just pick up the phone and call toll free 1-800-300-1063 .  And just to “sweeten the pot” as we say in my native state of Texas, Dr. Steenblock is offering consultations today!

Multiple Sclerosis: Dr. Steenblock’s “Whole Person” Approach

MS Multiple SclerosisMultiple Sclerosis (MS): Dr. Steenblock’s “Whole Person” Approach

If you or a loved one are among the 30,000 Americans with MS, reflect for a moment on what your principle physician has done so far to help you manage your condition. Most likely he has prescribed drugs to help reduce inflammation and symptom severity, plus perhaps a “healthy diet,” exercise program and possibly physical and other therapies. There is no question but that these approaches have helped many MS sufferers “muddle through,” though often with side effects and complications. Dr. Steenblock on-the-other-hand takes a more comprehensive or “whole body” approach to MS. Among the things he employs to help MS patients realize substantial clinical improvements that stick around:

(1) Identify and eradicate any infections, allergies and other contributors to inflammation including those in the GI track, gums or elsewhere.

(2) Test for toxic, tissue-damaging heavy metals and then remove any that are present in high amounts by means of IV chelation therapy.

(3) Identify and implement the best ways to foster repair of the MS patient’s leaky blood-brain barrier and remyelination of their demyelinated nerves. Among the many innovative treatment approaches that are part of Dr. Steenblock’s clinical repertoire:

(a) Dietary & Nutritional measures geared to reduce neuroinflammation and provide the body with what it needs to combat the MS autoimmune process, as well as repair and restore disease-ravaged tissues.

(b) Hyperbaric oxygen therapy (HBOT): HBOT helps reduce inflammation in the Central Nervous System (CNS) and increases oygen to diseased and hypoxic (oxygen-starved) tissues.

( c ) External counterpulsation (EECP): This noninvasive medical device painlessly and safely pushes blood from a patient’s legs and trunk to his heart, which results in better circulation. Although the FDA has only approved EECP to treat angina and congestive heart failure, Dr. Steenblock has found it to benefit MS patients when used in concert with HBOT (See b. above).

(d) Intravenous therapies: Many have similar effects to what you’ll find under (a) above, but work much quicker than dietary measures and supplements.

(e) Whole bone marrow transplants: Bone marrow contains stem cells that have been shown to help dampen the MS autoimmune attack on myelin and promote remyelination of demyelinated nerves. You will find some of these studies on http://www.stemcelltherapies.org/umresearch/ms-research2.html.

You can read more about Dr. Steenblock’s approach to MS in this free 33 page report: http://biotheorist.files.wordpress.com/2011/06/free-report-alternative-therapies-for-multiple-sclerosis1.pdf

If you’d like to discuss your case with Dr. Steenblock, you can do so anytime.  To arrange for your consultation just call 1-800-300-1063.

 

Stem Cells age with our Bodies but there are ways to Rejuvenate them

stem cellsStem Cells age with our Bodies but there are ways to Rejuvenate them

As this technical review that appeared in the prestigious journal NATURE signals, the stem cells in our bone marrow and elsewhere lose vitality as we age: “Stem cells, ageing and the quest for immortality” (NATURE review) by Thomas A. Rando.  Part of this is due to the fact the tissue environment (such as the extracellular matrix or ECM) in our bodies is littered with heavy metals, metabolic byproducts and more (Think of your ECM like a field filled with crops and seeds. If the soil becomes littered with impediments to the growth and health of plants then decline and die-off sets in.) Thankfully physician and stem cell expert Dr. Steenblock has come up with ways to revitalize the tissue micro-environment and also purge out old stem cells (which prods the body to replace them with new, healthier ones.) If you’d like to know more about Dr. Steenblock’s rejuvenation program you should: (1) Go to http://www.stemcellmd.org/?page_id=337 and read the posted report; and then (2) call Dr. Steenblock’s Clinic and request a  consultation. Just call toll free 1-800-300-1063.

Parkinson’s disease: Powerful preventative & treatment measures

Parkinson’s disease: Powerful preventative & treatment measures

As we say in Texas, Dr. Steenblock has “cored the apple” with respect to Parkinson’s disease:

“Parkinson’s patients have immune and detoxification problems compared to healthy people of the same age. They have exaggerated inflammatory responses to bacterial and fungal infections which may be due to the amounts of heavy metals like copper, iron, mercury and lead in their brain, intestinal tract and the rest of their body.  These metals accumulate in these people for a variety of reasons some of which are from environmental exposures including excessive consumption of heavy-metals sequestering fish and in some genetic issues and problems that together facilitate increased absorption of these heavy metals as well as intestinal bacteria and their cell wall components. Endotoxins and Bacteria derived peptide (fMLP) have been found to be toxic to dopamine neurons and cause selective dopamine neuron loss at very low levels- the type of levels that can be produced from straining to pass stool, poor dental care and from consuming too many salted nuts and seeds, refined sugars, acid foods, alcohol and other intestinal tract damaging substances that allow these bacterial and fungal poisons to migrate through the intestinal wall into the blood stream. From the blood, these endotoxins and bacteria derived peptides are picked up from the blood by the astroglia that line the brain’s blood vessels and whose function (in part) includes protecting delicate neurons from these toxins.  These poisons stimulate the blood-brain-barrier astroglia to make free radicals that cause damage to the nearby dopamine producing cells (and this by using up the free radical-scavenging glutathione normally present within astroglia that is needed to detoxify chemical poisons generated by internal metabolic processes or which enter the body from outside sources.)”

OK, so now you have insight into part of the disease process that gives rise to and fuels Parkinson’s disease. Where can you find out about other players? And what can you do to counter these “monkey wrenches in the cogs” or, where Parkinson’s disease already exists, remediate or even reverse it? One good place to start is this article: http://www.stemcellmd.org/?page_id=389 In it you will read about what powerful therapeutic measures for PD including the use of your own stem cell-rich bone marrow. You can learn more by calling Dr. Steenblock’s Clinic at 1-800-300-1063 and setting up a consultation!

The Power of Intermittent Hypoxia Therapy

Intermittent Hypoxia Therapy

The Power of Intermittent Hypoxia Therapy

Intermittent Hypoxia Therapy is a powerful therapeutic tool employed by Dr. Steenblock. Among the wondrous effects it has on the human body:

  • Increases collateral circulation.
  • Boosts the efficiency of the cell’s internal power-producers, the mitochondria.
  • Increases the number of mitochondria inside cells.
  • Bolsters a patient’s ability to handle stress as well as infections.

These websites will help flesh this out further:

www.hypoxico.com

www.go2Altitude.com

Dr. Steenblock often uses Intermittent Hypoxia Therapy to help mobilize a patient’s own stem cells prior to giving them a stem cell rich bone marrow treatment.

Curious as to what IHT might do to help address your health needs? A bone marrow treatment? You can find out for free by calling Dr. Steenblock’s Clinic at 1-800-300-1063 and asking for a consultation!

 

Stem Cell consultations!

Stem Cell TreatmentsStem Cell consultation!

Physician David Steenblock has based his medical career on finding solutions to health issues and problems that elude other doctors. Not surprisingly, “hopeless” and “no option” cases are his call-to-arms. He adamantly refuses to do “ho hum” or “prescription pad” medicine or give his patients less than his best. For over forty years now he has been on an indefatigable quest to find or craft novel solutions and ideas. If you are ready for the best, give Dr. Steenblock a call.  He is offering stem cell consultations today! To arrange for yours just call his clinic toll free at 1-800-300-1063.  

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